Hippy Sippy consisted of tiny chocolate balls packaged in a container that looked like a hypodermic needle. The chocolate balls were sucked out through the "needle." The candy was introduced in 1968, but was pulled from shelves within a year because of popular outrage.
It reminds me of the Chilly Bang! Bang! juice-filled squirt gun
More info: Box Vox
Camden Courier-Post - Oct 19, 1968
Sgt. Joseph Mitlof of the NYPD realized that the 30 cups of coffee a day he was drinking might have been contributing to his anxiety problems. In fact, he was suffering from "caffeinism."
Tallahassee Democrat - Mar 20, 1985
I had never heard of such a thing as "caffeinism," but it turns out the term is over 100 years old. A 1979 article in the Journal of Applied Behavior Analysis
offered the following definition:
Caffeinism describes a set of behavioral and physiological symptoms caused by the excessive consumption of caffeine-containing substances. The symptoms include nervous irritability, tremulousness, occasional muscle twitchings, insomnia, sensory disturbances, tachypnea (an abnormally rapid rate of breathing), palpitations, flushing, arrhythmias (an alteration or abnormality of normal cardiac rhythm), diureses, and gastrointestinal disturbances. Individuals suffering from caffeinism are sometimes misdiagnosed as anxiety neurotics because of the similarity of the symptoms. The deleterious effects of caffeine on humans also may include increasing the possibility of coronary heart disease in susceptible persons, promoting the progress of atherosclerosis and affecting chromosomal structure or action.
Burlington Daily Times - Mar 5, 1968
I only drink one cup of coffee a day, first thing in the morning. I think I'm good.
Same method, 95 years apart.
The Pittsburgh Press - Mar 8, 1922
Pigeon caught with backpack of drugs
BBC News - May 25, 2017
I had never heard of "reverse tolerance"
before, but apparently it's a real thing. It describes a condition in which some habitual users of a drug will, over time, require less of the drug (instead of more) to achieve the same effect. It's most often discussed with reference to marijuana, but sometimes alcohol also.
One theory is that marijuana accumulates in the body for a long time and that's what produces the effect -- i.e. you think you may be having just a little, but you've already got a lot in you. Another theory is that it's just a psychological illusion. As users become more familiar with how to smoke it, they do so more efficiently and learn to identify the effects earlier. Therefore, they think they need less to achieve the same effect.
When people develop a reverse tolerance to alchol, it's usually because of liver damage. They lose the ability to break down alcohol, so a little bit produces a big effect.
Minneapolis Star Tribune - Dec 18, 1970
St. Cloud Times - Feb 17, 1973
(above) is a type of sea bream found in the Mediterranean as well as in temperate areas of the Indian and Pacific Oceans. It has one unusual quality. Eating it can cause hallucinations. For this reason, it's sometimes called the "dreamfish."
People have known about this for a long time. Apparently Sarpa salpa
was occasionally eaten for recreational purposes during the Roman Empire.
A 2006 article in the journal Clinical Toxicology
describes some medical case reports involving dreamfish consumption. For instance, in 1994 a 40-year-old man on vacation in the French Riviera ate some, and the next day the hallucinations began:
he began to experience blurring of vision and hallucinations involving aggressive and screaming animals. Agitation and disorientation led him to seek medical assistance (he was not able to drive anymore as he was seeing giant arthropods around his car). Physical examination upon arrival at the hospital emergency room demonstrated no notable abnormalities: no fever, no sign of focalization or sensory-motor deficit, and normal hemodynamic status except for sinusal tachycardia linked directly to the mental disturbances. During hospitalization, the patient recovered rapidly with complete resolution of symptoms within 36 h post ingestion. He was unable to recall the hallucinatory period.
Similarly, in 2002 a 90-year-old retiree ate some sea bream, again in the French Riviera, and experienced hallucinations involving "human screams and bird squealing."
A case described on Wikipedia
seems to have been far more pleasurable. In 1960, National Geographic photographer Joe Roberts purposefully ate some broiled dreamfish: "he experienced intense hallucinations with a science-fiction theme that included futuristic vehicles, images of space exploration, and monuments marking humanity's first trips into space."
The authors of the Clinical Toxicology
article note that cases of hallucinogenic fish poisoning (ichthyoallyeinotoxism) are often confused with ciguatera poisoning — the latter caused by fish flesh contaminated by "various toxins produced by the benthic dinoflagellate Gambierdiscus toxicus
Ciguatera can also cause hallucinations. However, it may also kill you, whereas you should recover from the dreamfish hallucinations within 36 hours.
(Thanks to hotsauce269 for letting us know about the dreamfish.